KMAN Publication Inc. (KMANPUB) Applied Family Therapy Journal (AFTJ) 3041-8798 4 Serial Number 15 2023 03 01 Causal relationship between Depression and Health-related quality of life through chain mediation of Chronic Fatigue and Treatment Adherence in women with uterine cancer Causal relationship between Depression and Health-related quality of life through chain mediation of Chronic Fatigue and Treatment Adherence in women with uterine cancer 512 533 10.61838/kman.aftj.4.1.25 EN Journal Article <p>Aim: The aim of the present study was to investigate the causal relationship between depression and health-related quality of life through the chain mediation of chronic fatigue and adherence to treatment in women with uterine cancer. Method: In this descriptive correlational study, the statistical population consisted of all women diagnosed with uterine cancer in Mashhad in the year 2021, and 261 people were selected as a sample by purposive sampling. In this study, Health-related quality of life of Weber (1992), Depression of Beck (1996), Chronic fatigue of Chalder et al (1993), Treatment Adherence of Seyyed Fatemi, Rafiei, Hajizadeh &amp; Madanlo (2018) were used for data collection in this study. The data were analyzed using Pearson's correlation coefficient and path analysis model with the help of SPSS-27 and AMOS-25 software. Results: The findings showed the relationship between depression and health-related quality of life; between depression and chronic fatigue; between chronic fatigue and adherence to treatment; There was a significant relationship between adherence to treatment and health-related quality of life (p&lt;0.01); Also, the indirect path of depression with health-related quality of life with the mediating role of chronic fatigue and adherence to treatment were significant (p&lt;0.01). Conclusion: Based on the results of this research, the proposed model had a favorable fit and is considered an important step in the direction of knowing the factors affecting the quality of life related to the health of women with uterine cancer.</p> uterine cancer, health-related quality of life, depression, chronic fatigue and adherence to treatment. https://journals.kmanpub.com/index.php/aftj/article/download/1692/2061