KMAN Publication Inc. Journal of Poultry Sciences and Avian Diseases 2981-135X 2 Serial Number 8 2024 10 01 The effect of brain-derived neurotrophic factor (BDNF) on food consumption of broilers: Role of serotonergic receptors The effect of brain-derived neurotrophic factor (BDNF) on food consumption of broilers: Role of serotonergic receptors 1 8 EN Journal Article 2024 04 27 <p>Previously, the effects of brain-derived neurotrophic factor (BDNF) on feed intake of mammals were studied, however, its role in avian feeding regulation remains unclear. Therefore, the present study aimed to investigate the possible effects of BDNF on the food consumption of broilers and its interaction with the serotonergic system. In the first treatment, broilers received intracerebroventricular (ICV) infusion of BDNF (7.5, 15, and 30 μg). BDNF (30 μg), Fluoxetine (10 μg), a serotonin reuptake inhibitor, and BDNF + Fluoxetine were injected in the second treatment. In subsequent treatments, instead of Fluoxetine, PCPA (serotonin synthesis inhibitor, 1.25 μg), SB242084 (antagonist of 5-HT2C receptor, 1.5 µg), and 8-OH-DPAT (agonist of 5-HT1A receptor, 15.25 nmol) were applied. Then, total food intake was recorded for 2 hours. According to the results, BDNF injection (15 and 30 μg) caused a significant decrease in the food intake of broilers compared to the control group (P&lt;0.05). Simultaneous administration of PCPA and SB242084 with BDNF suppressed BDNF-induced hypophagia (P&lt;0.05), while the injection of fluoxetine + BDNF strengthened this hypophagic effect (P&lt;0.05). The decrease in feed intake caused by BDNF was not significantly changed by simultaneous injection of BDNF + 8-OH-DPAT (P≥0.05). According to the findings, it seems that BDNF reduces food consumption in broilers and this effect is probably mediated via 5-HT2c receptors.</p> https://journals.kmanpub.com/index.php/jpsad/article/download/4720/8536