Health Anxiety and Quality of Life Among Patients With Cardiovascular Disease: The Mediating Role of Emotion Regulation Difficulties
Keywords:
Health anxiety, Quality of life, Cardiovascular disease, Emotion regulation difficulties, Mediation, Cardiac patientsAbstract
Objective: This study aimed to investigate the relationship between health anxiety and quality of life among patients with cardiovascular disease and to examine the mediating role of emotion regulation difficulties in this relationship.
Methods and Materials: This descriptive-correlational cross-sectional study was conducted on 312 patients with cardiovascular disease who were receiving outpatient cardiology follow-up or cardiac rehabilitation services in Germany. Participants were selected through purposive sampling based on the inclusion and exclusion criteria. Data were collected using a demographic and clinical information form, the Short Health Anxiety Inventory, the Difficulties in Emotion Regulation Scale, and the MacNew Heart Disease Health-Related Quality of Life Questionnaire. Data were analyzed using SPSS and AMOS. Pearson correlation coefficients were used to examine relationships among variables, and path analysis was conducted to test the mediation model. The significance of the indirect effect was assessed using the bootstrapping method with 5,000 resamples and 95% confidence intervals.
Findings: Health anxiety was significantly and positively correlated with emotion regulation difficulties (r = 0.58, p < .01) and significantly and negatively correlated with quality of life (r = -0.49, p < .01). Emotion regulation difficulties were also significantly and negatively correlated with quality of life (r = -0.62, p < .01). The mediation model showed acceptable fit indices (χ²/df = 2.16, CFI = 0.989, TLI = 0.963, RMSEA = 0.061, SRMR = 0.018). Health anxiety significantly predicted emotion regulation difficulties (β = 0.56, p < .001), and emotion regulation difficulties significantly predicted quality of life (β = -0.47, p < .001). The direct effect of health anxiety on quality of life remained significant (β = -0.25, p < .001). The indirect effect was also significant (β = -0.27, 95% CI [-0.042, -0.022]), indicating partial mediation.
Conclusion: Emotion regulation difficulties partially mediated the relationship between health anxiety and quality of life among patients with cardiovascular disease, suggesting that emotional dysregulation is an important psychological mechanism through which health anxiety may reduce perceived quality of life.
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References
Bernad, B. C., Tomescu, M. C., Velimirovici, D. E., Andor, M., Lungeanu, D., Enătescu, V., & Hogea, L. (2025). Impact of Stress and Anxiety on Cardiovascular Health in Pregnancy: A Scoping Review. Journal of clinical medicine, 14(3), 909. https://doi.org/10.3390/jcm14030909
Cutajar, K., & Bates, G. (2025). Australian Women in the Perinatal Period During COVID-19: The Influence of Self-Compassion and Emotional Regulation on Anxiety, Depression, and Social Anxiety. Healthcare, 13(2), 120. https://doi.org/10.3390/healthcare13020120
Dona, S. W. A., McKenna, K., Ho, T. Q. A., Mudiyanselage, S. B., Seymour, M., Le, H. N., & Gold, L. (2025). Health-related quality of life, service utilisation and costs for anxiety disorders in children and young people: a systematic review and meta-analysis. Social Science & Medicine, 373, 118023. https://doi.org/10.1016/j.socscimed.2025.118023
He, Z.-Q., Wang, Q., Xu, C.-Y., Yang, J., & Huang, Y.-J. (2024). Depression and anxiety symptom network structure among patients with coronary heart disease and association with quality of life: protocol for a multicentre cross-sectional and prospective longitudinal study. BMJ open, 14(2), e079298. https://doi.org/10.1136/bmjopen-2023-079298
Juranek, J., Wojtkiewicz, M., Juranek, J. K., Szuszkiewicz, J., Jóżwik, M., & Wojtkiewicz, J. (2025). The Effects of General Mental Health Symptomatology, COVID Anxiety, and Sociodemographic Factors on Pandemic-Induced Negative and Positive Trauma Effects: A Polish Survey From the Late Stages of the Pandemic. Journal of clinical medicine, 14(10), 3343. https://doi.org/10.3390/jcm14103343
Lan, L., Liu, W., Liu, C., Wang, H., Wang, M., Abbey, C., & Tong, L. (2024). Effects of mindfulness and life-skills training on emotion regulation and anxiety symptoms in Chinese migrant children: A randomized controlled trial. Journal of Adolescent Health, 75(3), 404-415. https://doi.org/10.1016/j.jadohealth.2024.05.024
Marcondes, L., Ferreira, P. M., Sawada, N. O., Chianca, T. C. M., Félix, J. V. C., Guimarães, P. R. B., & Kalinke, L. P. (2025). Effect of Laser Auriculotherapy on Quality of Life, Fatigue, and Anxiety in Women With Advanced Breast Cancer: Randomized Clinical Trial. Healthcare, 13(2), 166. https://doi.org/10.3390/healthcare13020166
Mousavi, S., Heidari, A., Safarzadeh, S., Asgari, P., & Talebzadeh Shoushtari, M. (2024). The Effectiveness of Emotional Schema Therapy on Self-Regulation and Frustration Tolerance in Female Students with Exam Anxiety. Women's Health Bulletin.
Park, C. S., Choi, E.-K., Han, K.-D., Ahn, H.-J., Kwon, S., Lee, S.-R., Oh, S., & Lip, G. Y. H. (2023). Increased cardiovascular events in young patients with mental disorders: a nationwide cohort study. European Journal of Preventive Cardiology, 30(15), 1582-1592. https://doi.org/10.1093/eurjpc/zwad102
Regzedmaa, E., Ganbat, M., Sambuunyam, M., Tsogoo, S., Radnaa, O., Lkhagvasuren, N., & Zuunnast, K. (2024). A systematic review and meta-analysis of neuroticism and anxiety during the COVID-19 pandemic [Systematic Review]. Frontiers in Psychiatry, 14. https://doi.org/10.3389/fpsyt.2023.1281268
Sauletzhanovna, T. A., Mohammed, W. K., Ahmed, A. S., Mohammed, H. I., Al-Hili, A., Alnajar, M. J., Naser, N. S., Amr, E. F., & Mohsin, R. M. (2024). The Predictive Value of Depression and Anxiety on Protracted Cardiovascular Outcomes in Individuals with Acute Myocardial Infarction: The predictive value of depression and anxiety on protracted cardiovascular outcomes. International Journal of Body, Mind and Culture, 11(Special Issue), 64-75. https://doi.org/10.22122/ijbmc.v10iSpecial Issue.739
Shang, C., Zhang, Q., Pang, X., Wei, Y., Huang, Y., & Cui, L. (2024). Emotion beliefs, emotion regulation strategies, and test anxiety of Chinese adolescents in grade 8: Evidence from physiological recordings during an exam. Stress and Health, 40(4), e3376. https://doi.org/10.1002/smi.3376
Shen, K., Kuyvenhoven, C., Carruthers, A., Pahwa, M., Hadid, D., Greyson, D., Bayrampour, H., Liauw, J., Mniszak, C., & Vanstone, M. (2024). Seeking Mental Health Support for Feelings of Perinatal Depression and/or Anxiety During the COVID-19 Pandemic: A Qualitative Descriptive Study of Decision-Making. Women S Health, 20. https://doi.org/10.1177/17455057241282258
Silva, I., Meireles, A. L., Carolina Martins dos Santos, C., Cardoso, C. S., Oliveira, H. N. d., Freitas, E. D. d., Vidigal, F. d. C., Nobre, L. N., Silva, L. S. d., Paula, W. d., & Ferreira, L. G. (2025). Emotional Eating and Its Relationship With Symptoms of Anxiety, Depression, and Stress During the COVID-19 Pandemic: A Multicenter Study in College Students. International journal of environmental research and public health, 22(3), 354. https://doi.org/10.3390/ijerph22030354
Sun, J., & Zhang, L. (2024). Quality of life, anxiety, and mindfulness during COVID-19: A comparative study in medical vs non-medical students. BMC public health, 24, 20477. https://doi.org/10.1186/s12889-024-20477-x
Talebi, G., Rezayi Jamaloui, H., Bagherian Sararodi, R., Oreyzi, H., & Bagherian-Sararoudi, P. (2024). Effectiveness of Meaning-Centered Group Therapy on Death Attitude and Distress Tolerance in Women with Breast Cancer with Death Anxiety. Health Psychology, 13(51), 83-98. https://doi.org/10.30473/hpj.2024.68761.5874
Thiria, E., Pellegrini, C., Kase, B. E., DeVivo, K., & Steck, S. E. (2024). Health behavior and anxiety changes during the COVID-19 pandemic among students, faculty, and staff at a US university. Journal of American College Health, 72(7), 2180-2187. https://doi.org/10.1080/07448481.2022.2104615
Zhang, J., Li, X., Tang, Z., Xiang, S., Tang, Y., Hu, W., Tan, C., & Wang, X. (2024). Effects of stress on sleep quality: multiple mediating effects of rumination and social anxiety. Psicologia: Reflexão e Crítica, 37(1), 10. https://doi.org/10.1186/s41155-024-00294-2
Zhang, X., & Yan, S. (2024). Comment on "The effect of psychological inflexibility on health-related quality of life, depression, and anxiety in patients with chronic tinnitus without hearing loss. Revista Da Associação Médica Brasileira, 70(5), e20231734. https://doi.org/10.1590/1806-9282.20231734
Zitzmann, J., Rombold-George, L., Rosenbach, C., & Renneberg, B. (2024). Emotion Regulation, Parenting, and Psychopathology: A Systematic Review. Clinical Child and Family Psychology Review, 27(1), 1-22. https://doi.org/10.1007/s10567-023-00452-5
Μangoulia, P., Kanellopoulou, A., Manta, G., Chrysochoou, G., Dimitriou, E., Kalogerakou, T., & Αντωνιάδου, Μ. (2024). Exploring the Levels of Stress, Anxiety, Depression, Resilience, Hope, and Spiritual Well-Being Among Greek Dentistry and Nursing Students in Response to Academic Responsibilities Two Years After the COVID-19 Pandemic. Healthcare, 13(1), 54. https://doi.org/10.3390/healthcare13010054
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Copyright (c) 2025 Francesca Lombardi (Author); Florian Reimann

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