The Effectiveness of Acceptance and Commitment Therapy on Psychological Flexibility, Pain Catastrophizing, and Quality of Life Among Adults With Chronic Pain
Keywords:
Acceptance and Commitment Therapy, Chronic Pain, Psychological Flexibility, Pain Catastrophizing, Quality of LifeAbstract
Objective: This study aimed to determine the effectiveness of Acceptance and Commitment Therapy on psychological flexibility, pain catastrophizing, and quality of life among adults with chronic pain.
Methods and Materials: This quasi-experimental study was conducted using a pretest–posttest design with a control group and a two-month follow-up. The statistical population included adults with chronic pain who referred to pain clinics, rehabilitation centers, and specialized medical centers in Isfahan, Iran. A total of 50 eligible participants were selected through purposive sampling and assigned to an experimental group and a control group, with 25 participants in each group. The experimental group received Acceptance and Commitment Therapy in eight weekly 90-minute sessions, while the control group received routine care and no structured psychological intervention during the same period. Data were collected using the Psychological Inflexibility in Pain Scale, the Pain Catastrophizing Scale, and the 36-Item Short Form Health Survey. Data were analyzed using repeated-measures analysis of variance and Bonferroni post hoc comparisons.
Findings: The results showed a significant main effect of time for pain-related psychological inflexibility, pain catastrophizing, and quality of life (p < .001). The main effect of group was also significant for all three variables (p < .001). Most importantly, the time-by-group interaction was significant for pain-related psychological inflexibility (F = 44.93, p < .001, η² = .484), pain catastrophizing (F = 39.84, p < .001, η² = .454), and quality of life (F = 47.28, p < .001, η² = .496). Bonferroni comparisons indicated significant improvements from pretest to posttest and from pretest to follow-up in the experimental group (p < .001), while posttest-to-follow-up differences were not significant.
Conclusion: Acceptance and Commitment Therapy was effective in improving psychological flexibility, reducing pain catastrophizing, and enhancing quality of life among adults with chronic pain, and these effects remained stable at the two-month follow-up.
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References
Aboushaar, N., & Serrano, N. (2024). The Mutually Reinforcing Dynamics Between Pain and Stress: Mechanisms, Impacts and Management Strategies. Frontiers in Pain Research, 5. https://doi.org/10.3389/fpain.2024.1445280
Adhikary, D., Barman, S., & Ranjan, R. (2023). Internet-Based Cognitive Behavioural Therapy for Individuals With Depression and Chronic Health Conditions: A Systematic Review. Cureus. https://doi.org/10.7759/cureus.37822
Anagnostopoulos, F., Paraponiari, A., & Kafetsios, K. (2022). The Role of Pain Catastrophizing, Emotional Intelligence, and Pain Intensity in the Quality of Life of Cancer Patients With Chronic Pain. Journal of Clinical Psychology in Medical Settings, 30(3), 501-519. https://doi.org/10.1007/s10880-022-09921-5
Bäckryd, E., Ghafouri, N., Gerdle, B., & Dragioti, E. (2024). Rehabilitation Interventions for Neuropathic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Rehabilitation Medicine, 56, jrm40188. https://doi.org/10.2340/jrm.v56.40188
Beaulieu, D., Daley, A., Gaudet, D., Proctor, C. J., Hickey, P., & Best, L. A. (2024). Facing Challenges: The Positive Impact of Psychological Flexibility. https://doi.org/10.36315/2024inpact163
Black, W. R., Christofferson, J., Connelly, M., Goubert, L., Wallace, D. P., Ellingson‐Sayen, L. D., & Davis, A. M. (2025). Resilience Factors and Physical Activity Engagement in Adolescents With Chronic Musculoskeletal Pain: A Cross-Sectional Study. Journal of clinical medicine, 14(21), 7621. https://doi.org/10.3390/jcm14217621
Castaño-Asins, J. R., Sanabria‐Mazo, J. P., Luciano, J. V., Barceló‐Soler, A., Martín‐Lopez, L. M., Arco-Churruca, A. D., Lafuente-Baraza, J., Bulbena, A., Pérez, V., & Montes-Pérez, A. (2023). Effectiveness of Acceptance and Commitment Therapy (ACT) for the Management of Postsurgical Pain: Study Protocol of a Randomized Controlled Trial (SPINE-ACT Study). Journal of clinical medicine, 12(12), 4066. https://doi.org/10.3390/jcm12124066
Damci, A., Hollander, M. d., Hoeijmakers, J. G. J., Faber, C. G., Mariëlle, E. J. B. G., & Verbunt, J. (2024). Biopsychosocial Rehabilitation Therapy in Small Fiber Neuropathy: Research Protocol to Study the Effect of Rehabilitation Treatment. Frontiers in Neurology, 15. https://doi.org/10.3389/fneur.2024.1493326
Daniëlle, L. v. d. G., Mols, F., Trompetter, H. R., Marije, L. v. d. L., Schreurs, K. M. G., Børøsund, E., Nes, L. S., & Smeets, T. (2022). Effectiveness of the Online Acceptance and Commitment Therapy Intervention “Embrace Pain” for Cancer Survivors With Chronic Painful Chemotherapy-Induced Peripheral Neuropathy: Study Protocol for a Randomized Controlled Trial. Trials, 23(1). https://doi.org/10.1186/s13063-022-06592-3
Edwards, K. A., Reed, D. E., Anderson, D. R., Harding, K. A., Turner, A. P., Soares, B., Suri, P., & Williams, R. M. (2023). Opening the Black Box of Psychological Treatments for Chronic Pain: A Clinical Perspective for Medical Providers. Pm&r, 15(8), 999-1011. https://doi.org/10.1002/pmrj.12912
Edwards, K. A., & Vowles, K. E. (2022). Acceptance and Commitment Therapy for Chronic Pain. 432-454. https://doi.org/10.1093/oxfordhb/9780197550076.013.33
Fang, S., & Ding, D. (2022). Which Outcome Variables Are Associated With Psychological Inflexibility/Flexibility for Chronic Pain Patients? A Three Level Meta-Analysis. Frontiers in psychology, 13. https://doi.org/10.3389/fpsyg.2022.1069748
Foustoukos, T. L., Blanchard, M., & Hügle, T. (2024). Evidence-Based Self-Management Strategies for Fibromyalgia: Foundations for Digital Therapeutic Applications (Preprint). https://doi.org/10.2196/preprints.67523
Galvez-Sánchez, C. M., Montoro, C. I., Moreno‐Padilla, M., Gustavo, A. R. d. P., & Coba, P. d. l. (2021). Effectiveness of Acceptance and Commitment Therapy in Central Pain Sensitization Syndromes: A Systematic Review. Journal of clinical medicine, 10(12), 2706. https://doi.org/10.3390/jcm10122706
Garmendia, J., Angeard, N., Braakman, H. M. H., Bruggen, M. v., Cassiano Cesar de Carvalho, P., Piccolo, T. d. C., Chanteux, F., Engelen, B. G. v., Gallais, B., Zaldua, J. G., Graham, C. D., Groot, I. d., Hendriksen, J. G., Klinkenberg, S., Kroneman, M., Labayru, G., Muslemani, S., Nobile, M., Padua, L., . . . Young, P. (2023). 267th ENMC International Workshop: Psychological Interventions for Improving Quality of Life in Slowly Progressive Neuromuscular Disorders. Neuromuscular Disorders, 33(7), 562-569. https://doi.org/10.1016/j.nmd.2023.03.012
Gosens, T., & Oudsten, B. L. D. (2023). Psychology in Orthopedics and Traumatology: An Instructional Review. Efort Open Reviews, 8(5), 245-252. https://doi.org/10.1530/eor-23-0038
Keefer, L., Ko, C. W., & Ford, A. C. (2021). AGA Clinical Practice Update on Management of Chronic Gastrointestinal Pain in Disorders of Gut–Brain Interaction: Expert Review. Clinical Gastroenterology and Hepatology, 19(12), 2481-2488.e2481. https://doi.org/10.1016/j.cgh.2021.07.006
Kim, S., Whibley, D., Williams, D. A., & Kratz, A. L. (2020). Pain Acceptance in People With Chronic Pain and Spinal Cord Injury: Daily Fluctuation and Impacts on Physical and Psychosocial Functioning. Journal of Pain, 21(3-4), 455-466. https://doi.org/10.1016/j.jpain.2019.08.014
Kolokotroni, P., & Anagnostopoulos, F. (2025). The Impact of Cognitive and Existential Factors on Pain Experience and How Pain Relates to Cancer Survivors’ Fear of Recurrence: A Systematic Review. Journal of Health Psychology, 30(12), 3359-3377. https://doi.org/10.1177/13591053251324249
Ledermann, K. (2023). A Psychosomatic Perspective on Endometriosis – A Mini Review. Cortica, 2(1), 197-214. https://doi.org/10.26034/cortica.2023.3778
Lu, Y., Li, Y., Deng, Q., Zhao, X., Zhong, L.-L., & Yang, L. (2024). Acceptance and Commitment Therapy for Patients With Chronic Pain: A Systematic Review and Meta-Analysis on Psychological Outcomes and Quality of Life. PLoS One, 19(6), e0301226. https://doi.org/10.1371/journal.pone.0301226
Luciano, J. V., Neblett, R., Peñacoba, C., Suso‐Ribera, C., & McCracken, L. M. (2023). The Contribution of the Psychologist in the Assessment and Treatment of Fibromyalgia. Current Treatment Options in Rheumatology, 9(2), 11-31. https://doi.org/10.1007/s40674-023-00200-4
Meier, S., Ray, K. L., Waller, N., Gendron, B. C., Aytur, S., & Robin, D. A. (2020). Network Analysis of Induced Neural Plasticity Post-Acceptance and Commitment Therapy for Chronic Pain. Brain Sciences, 11(1), 10. https://doi.org/10.3390/brainsci11010010
Morcillo-Muñoz, Y., Sánchez-Guarnido, A. J., Calzón-Fernández, S., & Baena-Parejo, I. (2022). Multimodal Chronic Pain Therapy for Adults via Smartphone: Randomized Controlled Clinical Trial. Journal of medical Internet research, 24(5), e36114. https://doi.org/10.2196/36114
Osypiuk, K., Ligibel, J. A., Giobbie‐Hurder, A., Vergara-Díaz, G., Bonato, P., Quinn, R., Ng, W. T., & Wayne, P. M. (2020). Qigong Mind-Body Exercise as a Biopsychosocial Therapy for Persistent Post-Surgical Pain in Breast Cancer: A Pilot Study. Integrative Cancer Therapies, 19. https://doi.org/10.1177/1534735419893766
Pasini, I., Perlini, C., Donisi, V., Mason, A., Schweiger, V., Secchettin, E., Lugoboni, F., Valenza, G., & Piccolo, L. D. (2023). “INTEGRO INTEGRated Psychotherapeutic InterventiOn” on the Management of Chronic Pain in Patients With Fibromyalgia: The Role of the Therapeutic Relationship. International journal of environmental research and public health, 20(5), 3973. https://doi.org/10.3390/ijerph20053973
Prasad, S. A., Coskey, O., Wong, M. S., & Jones, J. D. (2025). The Movement, Mindfulness, and Pain Science (MMaPS) Class Improves Well‐Being and Physical Function in Patients With Chronic Pain. Musculoskeletal Care, 23(1). https://doi.org/10.1002/msc.70076
Roberts, M. Z., Scheiber, F., Moskovich, A. A., & Merwin, R. M. (2025). A Scoping Review of the Relationship Between Psychological (In)flexibility and Living With and Managing Type 1 and Type 2 Diabetes. Behavioral Sciences, 15(6), 792. https://doi.org/10.3390/bs15060792
Romero, M., Gómez-Hernández, M. B., Saz, A. P., Martínez-Monrobé, M. B., Gutiérrez-Fernández, N., Rodríguez, A. A., Garrido-Alfaro, R. A., Canal-Diez, N., Guerra-Martín, M. D., & Pereira-Delgado, C. (2025). Empowering Patients: A Multicomponent Workshop Improves Self-Management and Quality of Life in Chronic Pain. Medical Sciences, 13(4), 319. https://doi.org/10.3390/medsci13040319
Ruskin, D., Young, M., Sugar, C., & Nofech‐Mozes, J. (2021). Mindfulness and Acceptance Interventions for Parents of Children and Adolescents Diagnosed With Chronic Medical Conditions: A Systematic Review. The Journal of Alternative and Complementary Medicine, 27(2), 120-135. https://doi.org/10.1089/acm.2020.0191
Sakai, M., Kondo, M., Muto, T., Sugiura, T., & Akechi, T. (2023). Preliminary Utility of Group Acceptance and Commitment Therapy for Patients With Intractable Chronic Pain Presenting to a Multidisciplinary Pain Center in Japan: A Single-Arm Pre- And Post-Comparative Study. https://doi.org/10.21203/rs.3.rs-3262221/v1
Sakai, M., Kondo, M., Sugiura, T., & Akechi, T. (2022). Acceptance and Commitment Therapy in the Transdiagnostic Treatment of a Breast Cancer Survivor: A Case Study1. Japanese Psychological Research, 66(3), 264-275. https://doi.org/10.1111/jpr.12422
Serdarević, M. (2024). Chronic Pain Psychology in Neurology Practice. Continuum Lifelong Learning in Neurology, 30(5), 1501-1516. https://doi.org/10.1212/con.0000000000001471
Stiles‐Shields, C., Osos, S., Heilbrun, A., Feldman, E. C. H., Mak, G. Z., Skelly, C. L., & Drossos, T. (2021). Targeting Coping to Improve Surgical Outcomes in Pediatric Patients With Median Arcuate Ligament Syndrome: Feasibility Study. Frontiers in psychology, 12. https://doi.org/10.3389/fpsyg.2021.695435
Vasiliou, V. S., Karademas, E. C., Christou, Y., Papacostas, S., & Karekla, M. (2021). Mechanisms of Change in Acceptance and Commitment Therapy for Primary Headaches. European Journal of Pain, 26(1), 167-180. https://doi.org/10.1002/ejp.1851
Wu, Y.-Q., Long, Y., Peng, W., Gong, C., Liu, Y.-Q., Peng, X.-M., Zhong, Y.-B., Luo, Y., & Wang, M. (2023). The Efficacy and Safety of Telerehabilitation for Fibromyalgia: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of medical Internet research, 25, e42090. https://doi.org/10.2196/42090
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